Prof. Dr. Elmar Weinhold



Elmar Weinhold

Institute of Organic Chemistry


+49 241 80 94044



Bioconjugation, Enzyme, Nucleic Acids, Nucleoside, Synthesis

The main research activities are in the field of bioorganic chemistry/chemical biology and focus on the development of new molecular tools for functional genomics and proteomics. These tools are mainly based on methyltransferases (MTases), a class of enzymes that methylates various substrates like DNA, RNA, proteins and small molecules and serves a broad variety of biological functions ranging from epigenetics to metabolism.



Organic synthesis (cofactor analogues, modified oligonucleotides), biophysical chemistry (fluorescent binding studies), biochemistry (labeling of DNA, RNA and proteins, photo-cross­linking)



Searching for applications of AdoMet analogues in biological methylations (in vitro and in vivo) and in sequence-specific labeling of DNA, RNA or proteins (SMILing, mTAG).



  1. S. Willnow, M. Martin, B. Lüscher, E. Weinhold, A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. ChemBioChem 2012, 13, 1167–1173.
  2. S. Kim, A. Gottfried, R. R. Lin, T. Dertinger, A. S. Kim, S. Chung, R. A. Colyer, E. Weinhold, S. Weiss, Y. Ebenstein, Enzymatically Inccorporated Genomic Tags for Optical Mapping of DNA-Binding Proteins. Angew. Chem. Int. Ed. 2012, 51, 3578–3581.
  3. C. Dalhoff, M. Hüben, T. Lenz, P. Poot, E. Nordhoff, H. Köster, E. Weinhold. Synthesis of
    S-adenosyl-l-homocysteine capture compounds for selective photo-induced isolation of methyltransferases. ChemBioChem 2010, 11, 256–265.