Prof. Dr. Elmar Weinhold
Bioconjugation, Enzyme, Nucleic Acids, Nucleoside, Synthesis
The main research activities are in the field of bioorganic chemistry/chemical biology and focus on the development of new molecular tools for functional genomics and proteomics. These tools are mainly based on methyltransferases (MTases), a class of enzymes that methylates various substrates like DNA, RNA, proteins and small molecules and serves a broad variety of biological functions ranging from epigenetics to metabolism.
Organic synthesis (cofactor analogues, modified oligonucleotides), biophysical chemistry (fluorescent binding studies), biochemistry (labeling of DNA, RNA and proteins, photo-crosslinking)
Searching for applications of AdoMet analogues in biological methylations (in vitro and in vivo) and in sequence-specific labeling of DNA, RNA or proteins (SMILing, mTAG).
- S. Willnow, M. Martin, B. Lüscher, E. Weinhold, A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. ChemBioChem 2012, 13, 1167–1173.
- S. Kim, A. Gottfried, R. R. Lin, T. Dertinger, A. S. Kim, S. Chung, R. A. Colyer, E. Weinhold, S. Weiss, Y. Ebenstein, Enzymatically Inccorporated Genomic Tags for Optical Mapping of DNA-Binding Proteins. Angew. Chem. Int. Ed. 2012, 51, 3578–3581.
- C. Dalhoff, M. Hüben, T. Lenz, P. Poot, E. Nordhoff, H. Köster, E. Weinhold. Synthesis of
S-adenosyl-l-homocysteine capture compounds for selective photo-induced isolation of methyltransferases. ChemBioChem 2010, 11, 256–265.