Prof. Dr. Stefan Gründer
Ionchannels, Electrophysiology, Patchclamp, Site-Directed Mutagenesis
We have a focus on acid-sensing ion channels (ASICs), which have a potential role in neuronal degeneration associated with stroke and neuronal inflammation. Therefore, small molcule inhibitors of these channels are highly desired. Another focus is the related bile acid sensing ion channel (BASIC or BLINaC) which has unknown physiological functions. Small molecule inhibitors could help to unravel the role of BASIC/BLINaC.
Electrophysiology: Two-electrode voltage clamp with Xenopus oocytes, excised patches and
single channel analysis; whole cell patch clamp with cell lines and primary neuronal cultures
Confocal microscopy; Molecular Biology
- Support to develop novel small molecule inhibitors and modulators of ASICs and BASIC.
- Support to synthesize unnatural amino acids for structure-function studies.
- Chen X, Kalbacher H und Gründer S
The tarantula toxin Psalmotoxin 1 inhibits Acid Sensing Ion Channel (ASIC) 1a by increasing ist apparent H+ affinity.
J. Gen. Physiol. 126 (1), 71-79 (2005)
- Chen X, Paukert M, Kadurin I, Pusch M und Gründer S
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium.
Neuropharmacology, 50, 964-974 (2006)
- Wiemuth D und Gründer S
The pharmacologicalprofileofbrainliverintestine Na+channel (BLINaC): inhibition by diarylamidines and activation by fenamates.
Mol. Pharmacol., 80 (5), 911–919 (2011)
Wiemuth D, Sahin H, Falkenburger BH, Lefèvre C, Wasmuth HE und Gründer S
BASIC - a bile acid-sensitive ion channel highly expressed in bile ducts.
FASEB J., 26, 4122-4130 (2012)
Gründer S and Augustinowski K.
Toxin binding reveals two open state structures for one acid-sensing ion channel.
Channels, 6(6): 409-413 (2012)
Wiemuth D, Sahin H, Lefèvre C, Wasmuth HE und Gründer S
Strong activation of bile acid-sensitive ionchannel (BASIC) by ursodeoxycholic acid.
Channels, 7(1), 38-42 (2013)